Find out how Poxet 60 can amp your erection game

PE is a significant concern in male sexual health. PE is believed to have a worldwide incidence of between 20% and 40%, making it the most prevalent sexual disorder among males. Patients with PE experience discomfort and a decreased quality of life, as well as a detrimental influence on interpersonal interactions.

Historically, it was treated with cognitive therapy, behavioral techniques, and off-label usage of selective serotonin reuptake inhibitors (SSRIs), which are often used to treat depression and other psychiatric problems. Poxet 60 is a selective serotonin reuptake inhibitor that was developed exclusively for the treatment of PE. The purpose of this article is to summarize the existing data supporting the use of Poxet 60 in the treatment of PE in adult males.

There is compelling evidence that Poxet 60 30 mg or 60 mg administered “on-demand” increases intravaginal ejaculatory delay time significantly when compared to placebo. Patient-reported outcomes are significantly improved when Poxet 60 is used in comparison to placebo, indicating increased control over ejaculation, increased satisfaction with intercourse, decreased ejaculation-related distress, and, most importantly, significantly decreased interpersonal difficulty.

Consistent reports of improvement in Clinical Global Impression of change in PE after Poxet 60 therapy corroborated these findings. Additional research is required to determine long-term effectiveness and health economics. Poxet 60’s unique pharmacology makes it excellent for on-demand dosage, and clinical data supports its efficacy and tolerability as a therapy for lifelong and acquired PE.

Poxet 60 is the first and only prescription medication approved to treat premature ejaculation (PE) in males aged 18–64 years. Poxet 60 is now approved in 10 countries, including numerous European nations, as well as Mexico, South Korea, and New Zealand. PE is the most prevalent sexual disorder in males, with a worldwide frequency of between 20% and 40%.

The ambiguity around prevalence numbers stems from the condition’s personal character and, until recently, the absence of a universally accepted evidence-based definition. It is likely that many men are unaware they have the illness and do not seek medical attention.

PE is defined as pre- or post-vaginal penetration ejaculation with little stimulation, with the male having no control over ejaculation. The International Society for Sexual Medicine and the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) have both issued definitions, with the central point being the uncontrollable shortness of sexual intercourse. PE has severe negative implications for both male and female partners. Along with evident sexual dissatisfaction, the disorder may result in emotional misery, poor self-esteem, and interpersonal difficulties.

Poxet 60 is a member of the medication family known as selective serotonin reuptake inhibitors (SSRIs), which is widely used to treat depression. Prior to the availability of Poxet 60, PE was often treated with psychotherapy (e.g., cognitive behavior therapy). Recently, various selective serotonin reuptake inhibitors (SSRIs) (other than Poxet 60) have been used off-label to treat PE. These SSRIs were not created expressly for the treatment of PE, in contrast to Poxet 60, which was developed for this reason and has a unique pharmacological profile compared to the other SSRIs, as well as features that make it suited for on-demand dosage.

The purpose of this article is to summarize the current evidence supporting the use of Poxet 60 in the treatment of PE, including the drug’s ability to improve not only the time to ejaculation following penetration, referred to as intravaginal ejaculatory latency time (IELT), but also patient self-esteem, satisfaction with sexual intercourse, and perceived control over ejaculation.

PE is quite common and, because to the disorder’s nature, is likely to be under-reported and under-treated. Additionally, reported prevalence has been inconsistent owing to the prior absence of an evidence-based definition. In the past, doctors typically believed that PE had a psychological component, which is why psychotherapy was historically used to treat the ailment. However, since the biological component has been more recognized in recent years, medication has become the new emphasis for PE treatment.

Two distinct forms of PE have been extensively identified, namely primary (lifelong) and secondary (acquired) PE. PE persists beyond the initial sexual encounter, occurs in virtually all attempts at intercourse, and is thought to have a neurological cause. Secondary PE occurs later in life after a time of perceived normal ejaculatory control and may be caused by psychological or neurobiological factors. This form of PE may be induced by stress or may be connected with bad drug reactions. Waldinger et al. proposed that, in addition to these well-known kinds of PE, two other subtypes exist, namely natural variable PE and premature-like ejaculatory dysfunction. Natural variable PE refers to males who report experiencing occasional early ejaculation during routine activities, whilst the latter refers to men who encounter or complain of PE when undergoing normal or extended IELT.

Regardless of the classification, all PE share the following characteristics: an inability to control ejaculation, ejaculation prior to/soon after vaginal penetration, embarrassment, low self-esteem, personal distress, and frequently interpersonal difficulties and relationship problems as a result of the man’s and partner’s lack of sexual satisfaction. The International Society for Sexual Medicine recently published the first evidence-based definition of lifelong PE, which includes the criterion of “ejaculation that always or nearly always occurs prior to or within about 1 minute of vaginal penetration,” ie, an IELT of 1 minute or less.

Additionally, “… the inability to delay ejaculation on all or nearly all vaginal penetrations, and adverse personal consequences such as distress, bother, frustration, and/or avoidance of sexual intimacy” are specified. Previously, researchers recruiting patients for clinical studies of PE tended to use the DSM-IV-TR definition, which is similar to the one used by the International Society for Sexual Medicine but does not include an IELT cutoff.

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